NeuroD

Basic helix-loop-helix transcription factor

NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.[1] It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.[2]

In mammals there are two types of this factor:

  • NeuroD1
  • NeuroD2
  • NeuroD4
  • NeuroD6

References

  1. ^ Gu, Chunyan; Stein, Gretchen H.; Pan, Ning; Goebbels, Sandra; Hörnberg, Hanna; Nave, Klaus-Armin; Herrera, Pedro; White, Peter; Kaestner, Klaus H.; Sussel, Lori; Lee, Jacqueline E. (7 April 2010). "Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity". Cell Metabolism. 11 (4): 298–310. doi:10.1016/j.cmet.2010.03.006. ISSN 1550-4131. PMC 2855640. PMID 20374962.
  2. ^ Morrow, E.M.; Furukawa, T.; Lee, J.E.; Cepko, C.L. (1 January 1999). "NeuroD regulates multiple functions in the developing neural retina in rodent". Development. 126 (1): 23–36. doi:10.1242/dev.126.1.23. PMID 9834183. Retrieved 1 March 2022.


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Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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