HMGN2

Protein-coding gene in the species Homo sapiens

HMGN2

Identifiers

Aliases

HMGN2, HMG17, high mobility group nucleosomal binding domain 2

External IDs

OMIM: 163910; HomoloGene: 136792; GeneCards: HMGN2; OMA:HMGN2 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.11	Start	26,472,440 bp^[1]
Band	1p36.11	End	26,476,642 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

right uterine tube

pituitary gland

anterior pituitary

bone marrow cells

thyroid gland

endometrium

right lobe of thyroid gland

left lobe of thyroid gland

canal of the cervix

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleosomal DNA binding DNA binding protein binding RNA binding
Cellular component	chromatin extracellular space nucleus cytoplasm
Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3151


n/a

Ensembl


ENSG00000198830


n/a

UniProt


P05204


n/a

RefSeq (mRNA)


NM_005517


n/a

RefSeq (protein)


NP_005508


n/a

Location (UCSC)

Chr 1: 26.47 – 26.48 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.^[3]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198830 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dracopoli NC, O'Connell P, Elsner TI, Lalouel JM, White RL, Buetow KH, Nishimura DY, Murray JC, Helms C, Mishra SK, et al. (Jul 1991). "The CEPH consortium linkage map of human chromosome 1". Genomics. 9 (4): 686–700. doi:10.1016/0888-7543(91)90362-I. PMID 2037294.
^ "Entrez Gene: HMGN2 high-mobility group nucleosomal binding domain 2".

Giancotti V, Bandiera A, Buratti E, et al. (1991). "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein". Eur. J. Biochem. 198 (1): 211–6. doi:10.1111/j.1432-1033.1991.tb16003.x. PMID 2040281.
Popescu N, Landsman D, Bustin M (1990). "Mapping the human gene coding for chromosomal protein HMG-17". Hum. Genet. 85 (3): 376–8. doi:10.1007/BF00206764. PMID 2394451. S2CID 11160792.
Landsman D, McBride OW, Bustin M (1989). "Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family". Nucleic Acids Res. 17 (6): 2301–14. doi:10.1093/nar/17.6.2301. PMC 317597. PMID 2565024.
Landsman D, Soares N, Gonzalez FJ, Bustin M (1986). "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family". J. Biol. Chem. 261 (16): 7479–84. doi:10.1016/S0021-9258(17)38417-X. PMID 3754870.
Leffak M, Trempe JP (1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Res. 13 (13): 4853–69. doi:10.1093/nar/13.13.4853. PMC 321831. PMID 4022776.
Postnikov YV, Trieschmann L, Rickers A, Bustin M (1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". J. Mol. Biol. 252 (4): 423–32. doi:10.1006/jmbi.1995.0508. PMID 7563062.
Hock R, Scheer U, Bustin M (1999). "Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport". J. Cell Biol. 143 (6): 1427–36. doi:10.1083/jcb.143.6.1427. PMC 2132996. PMID 9852141.
Herrera JE, Sakaguchi K, Bergel M, et al. (1999). "Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes". Mol. Cell. Biol. 19 (5): 3466–73. doi:10.1128/MCB.19.5.3466. PMC 84139. PMID 10207070.
Kazmierczak B, Dal Cin P, Rogalla P, et al. (2000). "Regional fine mapping of HMG17 to chromosomal band 1p35". Cancer Genet. Cytogenet. 116 (2): 164–5. doi:10.1016/S0165-4608(99)00137-5. PMID 10640150.
Bergel M, Herrera JE, Thatcher BJ, et al. (2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". J. Biol. Chem. 275 (15): 11514–20. doi:10.1074/jbc.275.15.11514. PMID 10753971.
Bustin M (2001). "Revised nomenclature for high mobility group (HMG) chromosomal proteins". Trends Biochem. Sci. 26 (3): 152–3. doi:10.1016/S0968-0004(00)01777-1. PMID 11246012.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Birger Y, Ito Y, West KL, et al. (2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene". DNA Cell Biol. 20 (5): 257–64. doi:10.1089/104454901750232454. PMID 11410162.
Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.
Porkka K, Laakkonen P, Hoffman JA, et al. (2002). "A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7444–9. Bibcode:2002PNAS...99.7444P. doi:10.1073/pnas.062189599. PMC 124250. PMID 12032302.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.