HIC2

Protein-coding gene in the species Homo sapiens
HIC2
Identifiers
AliasesHIC2, HRG22, ZBTB30, ZNF907, hypermethylated in cancer 2, HIC ZBTB transcriptional repressor 2
External IDsOMIM: 607712; MGI: 1929869; HomoloGene: 9020; GeneCards: HIC2; OMA:HIC2 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for HIC2
Genomic location for HIC2
Band22q11.21Start21,417,371 bp[1]
End21,451,463 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for HIC2
Genomic location for HIC2
Band16|16 A3Start17,051,436 bp[2]
End17,081,294 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • amniotic fluid

  • endothelial cell

  • placenta

  • vena cava

  • Brodmann area 23

  • parotid gland

  • Region I of hippocampus proper

  • pancreatic ductal cell

  • thymus
Top expressed in
  • secondary oocyte

  • yolk sac

  • female urethra

  • abdominal wall

  • maxillary prominence

  • primitive streak

  • morula

  • wall of urinary bladder

  • mucosa of urinary bladder

  • medial ganglionic eminence
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein C-terminus binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23119

58180

Ensembl

ENSG00000169635

ENSMUSG00000050240

UniProt

Q96JB3

Q9JLZ6

RefSeq (mRNA)

NM_015094

NM_178922

RefSeq (protein)

NP_055909

NP_849253

Location (UCSC)Chr 22: 21.42 – 21.45 MbChr 16: 17.05 – 17.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
  6. ^ "Entrez Gene: HIC2 hypermethylated in cancer 2".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Young TM, Wang Q, Pe'ery T, Mathews MB (2003). "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (18): 6373–84. doi:10.1128/MCB.23.18.6373-6384.2003. PMC 193714. PMID 12944466.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMC 133903. PMID 12052894.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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