KIF5C

Protein-coding gene in the species Homo sapiens
KIF5C
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1VFV, 1VFW, 1VFX, 1VFZ, 3J6H, 3WRD, 3X2T

Identifiers
AliasesKIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2, kinesin family member 5C
External IDsOMIM: 604593; MGI: 1098269; HomoloGene: 56234; GeneCards: KIF5C; OMA:KIF5C - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KIF5C
Genomic location for KIF5C
Band2q23.1-q23.2Start148,875,227 bp[1]
End149,026,759 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for KIF5C
Genomic location for KIF5C
Band2 C1.1|2 28.68 cMStart49,509,310 bp[2]
End49,664,790 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 10

  • frontal pole

  • cerebellar vermis

  • middle temporal gyrus

  • middle frontal gyrus

  • Brodmann area 46

  • postcentral gyrus

  • Brodmann area 23

  • orbitofrontal cortex

  • endothelial cell
Top expressed in
  • globus pallidus

  • substantia nigra

  • cerebellar vermis

  • lateral geniculate nucleus

  • facial motor nucleus

  • ventral tegmental area

  • subiculum

  • lateral hypothalamus

  • pontine nuclei

  • medial geniculate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • microtubule binding
  • protein binding
  • plus-end-directed microtubule motor activity
  • ATP binding
  • ATPase activity
Cellular component
  • cytoplasm
  • kinesin complex
  • ciliary rootlet
  • neuron projection
  • microtubule
  • cytoskeleton
  • dendrite
  • dendrite cytoplasm
  • cell projection
  • neuronal cell body
  • axonal growth cone
  • synapse
  • distal axon
  • axon cytoplasm
Biological process
  • protein localization
  • cytoskeleton-dependent intracellular transport
  • mRNA transport
  • organelle organization
  • axon guidance
  • microtubule-based movement
  • motor neuron axon guidance
  • synaptic vesicle transport
  • anterograde dendritic transport of neurotransmitter receptor complex
  • anterograde axonal protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3800

16574

Ensembl

ENSG00000168280
ENSG00000276734

ENSMUSG00000026764

UniProt

O60282

P28738

RefSeq (mRNA)

NM_004522

NM_008449

RefSeq (protein)

NP_004513

NP_032475

Location (UCSC)Chr 2: 148.88 – 149.03 MbChr 2: 49.51 – 49.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene.[5][6] It is part of the kinesin family of motor proteins.


References

  1. ^ a b c ENSG00000276734 GRCh38: Ensembl release 89: ENSG00000168280, ENSG00000276734 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026764 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Niclas J, Navone F, Hom-Booher N, Vale RD (Jun 1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons". Neuron. 12 (5): 1059–72. doi:10.1016/0896-6273(94)90314-X. PMID 7514426. S2CID 32927183.
  6. ^ "Entrez Gene: KIF5C kinesin family member 5C".

Further reading

  • Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin". Hum. Mol. Genet. 6 (13): 2205–12. doi:10.1093/hmg/6.13.2205. PMID 9361024.
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Xia Ch; Rahman A; Yang Z; Goldstein LS (1998). "Chromosomal localization reveals three kinesin heavy chain genes in mouse". Genomics. 52 (2): 209–13. doi:10.1006/geno.1998.5427. PMID 9782088.
  • Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biol. Reprod. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC 3161965. PMID 11319135.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
  • Smith MJ, Pozo K, Brickley K, Stephenson FA (2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". J. Biol. Chem. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

  • Overview of all the structural information available in the PDB for UniProt: P28738 (Mouse Kinesin heavy chain isoform 5C) at the PDBe-KB.


  • v
  • t
  • e
  • 2kin: KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
    2kin: KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
  • 3kin: KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
    3kin: KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
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Hair keratins
(hard alpha-keratins)
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Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
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Nonhuman
See also: cytoskeletal defects


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