KIF18A

Protein-coding gene in the species Homo sapiens
KIF18A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3LRE

Identifiers
AliasesKIF18A, MS-PPP1R99, kinesin family member 18A
External IDsOMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for KIF18A
Genomic location for KIF18A
Band11p14.1Start28,020,619 bp[1]
End28,108,156 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for KIF18A
Genomic location for KIF18A
Band2|2 E3Start109,111,083 bp[2]
End109,172,092 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • gonad

  • testicle

  • secondary oocyte

  • ganglionic eminence

  • sperm

  • left testis

  • right testis

  • stromal cell of endometrium

  • bone marrow
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • spermatid

  • fetal liver hematopoietic progenitor cell

  • ventricular zone

  • genital tubercle

  • spermatocyte

  • epiblast

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • microtubule motor activity
  • tubulin-dependent ATPase activity
  • microtubule binding
  • microtubule plus-end binding
  • protein binding
  • actin binding
  • plus-end-directed microtubule motor activity
  • ATP binding
  • ATPase activity
Cellular component
  • cytoplasm
  • cytosol
  • cell projection
  • kinetochore microtubule
  • kinesin complex
  • ruffle
  • microtubule cytoskeleton
  • microtubule organizing center
  • mitotic spindle midzone
  • caveola
  • microtubule
  • cytoskeleton
  • nucleus
  • kinetochore
  • mitotic spindle astral microtubule
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • male meiotic nuclear division
  • regulation of microtubule cytoskeleton organization
  • microtubule-based movement
  • seminiferous tubule development
  • protein transport
  • microtubule depolymerization
  • mitotic metaphase plate congression
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • cellular response to estradiol stimulus
  • mitotic sister chromatid segregation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81930

228421

Ensembl

ENSG00000121621

ENSMUSG00000027115

UniProt

Q8NI77

Q91WD7

RefSeq (mRNA)

NM_031217

NM_139303

RefSeq (protein)

NP_112494

NP_647464

Location (UCSC)Chr 11: 28.02 – 28.11 MbChr 2: 109.11 – 109.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[5][6] It is part of the kinesin family of motor proteins.

Function

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121621 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027115 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: KIF18A kinesin family member 18A".
  7. ^ Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU (March 2007). "The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression". Current Biology. 17 (6): 488–498. Bibcode:2007CBio...17..488M. doi:10.1016/j.cub.2007.02.036. ISSN 0960-9822. PMID 17346968.

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Luboshits G, Benayahu D (2005). "MS-KIF18A, new kinesin; structure and cellular expression". Gene. 351: 19–28. doi:10.1016/j.gene.2005.02.009. PMID 15878648.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A
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See also: cytoskeletal defects


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