| KIF25 |
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| Identifiers |
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| Aliases | KIF25, KNSL3, kinesin family member 25 |
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| External IDs | OMIM: 603815 HomoloGene: 49939 GeneCards: KIF25 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6q27 | Start | 167,996,241 bp[1] |
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| End | 168,045,091 bp[1] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - abdominal fat
- putamen
- dorsolateral prefrontal cortex
- Brodmann area 9
- caudate nucleus
- substantia nigra
- nucleus accumbens
- prefrontal cortex
- amygdala
- hypothalamus
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - microtubule binding
- microtubule motor activity
- nucleotide binding
- ATPase activity
- ATP binding
- minus-end-directed microtubule motor activity
| | Cellular component | - cytoplasm
- microtubule
- cytoskeleton
- kinesin complex
- centrosome
- microtubule organizing center
| | Biological process | - microtubule-based movement
- negative regulation of autophagy
- organelle organization
- mitotic sister chromatid segregation
- negative regulation of mitotic centrosome separation
- protein homotetramerization
- establishment of spindle orientation
- nucleus localization
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 168 – 168.05 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Motor protein found in humans
Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.
Function
KIF25 is a minus-end directed microtubule motor protein, and its activity delays the separation of chromosomes during mitosis.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125337 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238. PMID 28263957.
