POLD2

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Polimeraza (DNK vođena), delta 2, pomoćna podjedinica
Dostupne strukture
3E0J
Identifikatori
SimbolPOLD2
Vanjski IDOMIM: 600815 MGI: 1097163 HomoloGene: 4538 GeneCards: POLD2 Gene
EC broj2.7.7.7
Ontologija gena
Molekulska funkcija • DNK vezivanje
• Akvivnost DNK vođene DNK polimeraze
• proteinsko vezivanje
Ćelijska komponenta • nukleus
• nukleoplazma
• nukleolus
Biološki proces • S faza mitotičkog ciklusa
• mitotički ćelijski ciklus
• telomerno održavanje rekombinacijom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez542518972
EnsemblENSG00000106628ENSMUSG00000020471
UniProtP49005O35654
Ref. Sekv. (iRNK)NM_001127218NM_008894
Ref. Sekv. (protein)NP_001120690NP_032920
Lokacija (UCSC)Chr 7:
44.15 - 44.16 Mb		Chr 11:
5.87 - 5.88 Mb
PubMed pretraga[1][2]

Delta podjedinica 2 DNK polimeraze je enzim koji je kod ljudi kodiran POLD2 genom.[1][2] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije

POLD2 formira interakcije sa PCNA.[3]

Reference

  1. ↑ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). „Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)”. Genomics 29 (1): 179–86. DOI:10.1006/geno.1995.1229. PMID 8530069. 
  2. ↑ „Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa”. 
  3. ↑ Lu, Xiaoqing; Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G (Jul 2002). „Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta”. J. Biol. Chem. (United States) 277 (27): 24340–5. DOI:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310. 

Literatura

  • Hindges R, Hübscher U (1997). „Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).”. Genomics 44 (1): 45–51. DOI:10.1006/geno.1997.4838. PMID 9286699. 
  • Hisama FM, Chen YH, Meyn MS i dr.. (2000). „WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts”. Cancer Res. 60 (9): 2372–6. PMID 10811112. 
  • Mo J, Liu L, Leon A i dr.. (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry 39 (24): 7245–54. DOI:10.1021/bi0000871. PMID 10852724. 
  • Perez A, Leon A, Lee MY (2000). „Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta”. Biochim. Biophys. Acta 1493 (1–2): 231–6. DOI:10.1016/s0167-4781(00)00153-6. PMID 10978529. 
  • Szekely AM, Chen YH, Zhang C i dr.. (2000). „Werner protein recruits DNA polymerase δ to the nucleolus”. Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. DOI:10.1073/pnas.97.21.11365. PMC 17206. PMID 11027336. 
  • He H, Tan CK, Downey KM, So AG (2001). „A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. DOI:10.1073/pnas.221452098. PMC 59753. PMID 11593007. 
  • Lu X, Tan CK, Zhou JQ i dr.. (2002). „Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta”. J. Biol. Chem. 277 (27): 24340–5. DOI:10.1074/jbc.M200065200. PMID 11986310. 
  • Ohta S, Shiomi Y, Sugimoto K i dr.. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Liu L, Rodriguez-Belmonte EM, Mazloum N i dr.. (2003). „Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen”. J. Biol. Chem. 278 (12): 10041–7. DOI:10.1074/jbc.M208694200. PMID 12522211. 
  • Scherer SW, Cheung J, MacDonald JR i dr.. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Lehner B, Sanderson CM (2004). „A Protein Interaction Framework for Human mRNA Degradation”. Genome Res. 14 (7): 1315–23. DOI:10.1101/gr.2122004. PMC 442147. PMID 15231747. 
  • Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Tsurimoto T, Shinozaki A, Yano M i dr.. (2005). „Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta”. Genes Cells 10 (1): 13–22. DOI:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. 
  • Rual JF, Venkatesan K, Hao T i dr.. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
  • p
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Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost • DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)