SIRT1

SIRT1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 4I5I、​4IF6、​4IG9、​4KXQ、​4ZZH、​4ZZI、​4ZZJ、​5BTR
識別號
别名	SIRT1；, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
外部ID	OMIM：604479 MGI：2135607 HomoloGene：56556 GeneCards：SIRT1
為以下藥物的標靶
SRT1720[1]
基因位置（人类） 染色体 10號染色體[2] 基因座 10q21.3 起始 67,884,656 bp[2] 终止 67,918,390 bp[2]
基因位置（小鼠） 染色体 小鼠10号染色体[3] 基因座 10|10 B4 起始 63,154,784 bp[3] 终止 63,217,483 bp[3]
RNA表达模式
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基因本體 分子功能 • transcription corepressor activity • protein domain specific binding • core promoter sequence-specific DNA binding • protein C-terminus binding • keratin filament binding • 转录因子结合 • 金屬離子結合 • HLH domain binding • 酶结合 • protein deacetylase activity • histone binding • 血浆蛋白结合 • NAD-dependent histone deacetylase activity • NAD-dependent protein deacetylase activity • histone deacetylase activity • p53 binding • mitogen-activated protein kinase binding • deacetylase activity • bHLH transcription factor binding • NAD+ binding • 相同蛋白质结合 • NAD+ ADP-ribosyltransferase activity • 水解酶活性 • NAD-dependent histone deacetylase activity (H3-K9 specific) • DNA-binding transcription activator activity, RNA polymerase II-specific 細胞組分 • 細胞質 • nuclear envelope • rDNA heterochromatin • chromatin silencing complex • 線粒體 • 细胞核 • ESC/E(Z) complex • 核仁 • 染色质 • 核质 • PML body • 內膜 • 细胞质基质 生物學過程 • cellular triglyceride homeostasis • positive regulation of MHC class II biosynthetic process • DNA synthesis involved in DNA repair • positive regulation of protein phosphorylation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • rhythmic process • single strand break repair • muscle organ development • histone H3-K9 deacetylation • negative regulation of cellular response to testosterone stimulus • regulation of peroxisome proliferator activated receptor signaling pathway • cellular response to DNA damage stimulus • regulation of bile acid biosynthetic process • 脫氧核糖核酸複製 • negative regulation of TOR signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of glucose metabolic process • rDNA heterochromatin assembly • negative regulation of DNA damage response, signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • 昼夜节律 • positive regulation of cellular senescence • 精子发生 • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to ionizing radiation • negative regulation of helicase activity • cholesterol homeostasis • response to leptin • cellular response to hypoxia • triglyceride mobilization • negative regulation of prostaglandin biosynthetic process • proteasome-mediated ubiquitin-dependent protein catabolic process • 细胞凋亡 • peptidyl-lysine deacetylation • negative regulation of fat cell differentiation • negative regulation of peptidyl-lysine acetylation • regulation of transcription, DNA-templated • positive regulation of adaptive immune response • stress-induced premature senescence • negative regulation of androgen receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of gene expression • transcription, DNA-templated • negative regulation of cAMP-dependent protein kinase activity • pyrimidine dimer repair by nucleotide-excision repair • response to insulin • histone H3-K9 modification • positive regulation of macroautophagy • positive regulation of cholesterol efflux • protein ubiquitination • negative regulation of cell growth • positive regulation of macrophage apoptotic process • rRNA processing • regulation of brown fat cell differentiation • negative regulation of phosphorylation • viral process • DNA修復 • negative regulation of neuron death • positive regulation of histone H3-K9 methylation • negative regulation of histone H3-K14 acetylation • negative regulation of protein kinase B signaling • 细胞分化 • ovulation from ovarian follicle • regulation of protein serine/threonine kinase activity • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • protein ADP-ribosylation • leptin-mediated signaling pathway • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • chromatin organization • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • protein deacetylation • fatty acid homeostasis • protein destabilization • regulation of mitotic cell cycle • positive regulation of cAMP-dependent protein kinase activity • white fat cell differentiation • positive regulation of insulin receptor signaling pathway • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • peptidyl-lysine acetylation • response to hydrogen peroxide • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of histone H4-K16 acetylation • positive regulation of endothelial cell proliferation • regulation of smooth muscle cell apoptotic process • behavioral response to starvation • cellular glucose homeostasis • cellular response to starvation • cellular response to tumor necrosis factor • positive regulation of DNA repair • multicellular organism development • regulation of cell population proliferation • positive regulation of cell population proliferation • regulation of endodeoxyribonuclease activity • regulation of cellular response to heat • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • UV-damage excision repair • histone deacetylation • positive regulation of transcription by RNA polymerase II • 血管新生 • macrophage cytokine production • regulation of lipid storage • positive regulation of adipose tissue development • macrophage differentiation • transcription by RNA polymerase II • positive regulation of smooth muscle cell differentiation • negative regulation of histone H3-K9 trimethylation • positive regulation of apoptotic process • cellular response to hydrogen peroxide • histone H3 deacetylation • negative regulation of protein acetylation • regulation of apoptotic process • cellular response to leukemia inhibitory factor • positive regulation of angiogenesis • transforming growth factor beta receptor signaling pathway • positive regulation of blood vessel endothelial cell migration • negative regulation of cellular senescence Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	23411	93759
Ensembl	ENSG00000096717	ENSMUSG00000020063
UniProt	Q96EB6	Q923E4
mRNA​序列	NM_001142498 ​NM_001314049 ​NM_012238	NM_001159589 ​NM_001159590 ​NM_019812
蛋白序列	NP_001135970 ​NP_001300978 ​NP_036370	NP_001153061 ​NP_062786
基因位置​（UCSC）	Chr 10: 67.88 – 67.92 Mb	Chr 10: 63.15 – 63.22 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

SIRT1（英語：Sirtuin 1），也被称为 NAD-依赖性去乙酰化酶Sirtuin-1（英語：NAD-dependent deacetylase sirtuin-1），是人类基因组中由SIRT1基因编码的蛋白。人的SIRT1基因位于10号染色体上。SIRT1的功能是去除蛋白质上的乙酰基团（去乙酰化）。SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用^[6][7][8]。

参考文献

外部链接

• Corante weblog by Derek Lowe about sir2 and SIRT1 research.

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