Leptină

LEP
Structuri disponibile PDB Căutare Ortholog: PDBe RCSB Coduri de identificare în PDB 1AX8
Identificatori
Alias	LEP
Identificări externe	OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP
Localizarea genei (om) Cro. Cromozomul uman 7[1] Bandă 7q32.1 Start 128,241,278 pb[1] Final 128,257,629 pb[1]
Modelul de exprimare ARN Mai multe date de referință pentru exprimare
Ontologia genei Funcția moleculară • activitate hormonală • peptide hormone receptor binding • signaling receptor binding Componenta celulară • citoplasmă • regiune extracelulară • spațiu extracelular Procesul biologic • regulation of protein phosphorylation • response to dietary excess • cellular response to retinoic acid • positive regulation of developmental growth • negative regulation of glucagon secretion • placenta development • cardiac muscle hypertrophy • regulation of angiogenesis • prostaglandin secretion • regulation of intestinal cholesterol absorption • T cell differentiation • positive regulation of reactive oxygen species metabolic process • central nervous system neuron development • Ritmul circadian • positive regulation of ion transport • angiogenesis • glucose metabolic process • positive regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of hepatic stellate cell activation • regulation of endothelial cell proliferation • intestinal absorption • response to ethanol • negative regulation of autophagy • positive regulation of p38MAPK cascade • positive regulation of protein kinase B signaling • negative regulation of metabolic process • negative regulation of vasoconstriction • glucose homeostasis • regulation of insulin secretion • regulation of steroid biosynthetic process • insulin secretion • regulation of natural killer cell activation • regulation of fat cell differentiation • response to vitamin E • response to nutrient levels • bone mineralization involved in bone maturation • positive regulation of T cell proliferation • positive regulation of protein import into nucleus • regulation of brown fat cell differentiation • fatty acid beta-oxidation • regulation of metabolic process • hormone metabolic process • positive regulation of MAPK cascade • positive regulation of TOR signaling • cellular response to L-ascorbic acid • ovulation from ovarian follicle • activation of protein kinase C activity • reproducere sexuată • negative regulation of cartilage development • response to nutrient • negative regulation of glutamine transport • leptin-mediated signaling pathway • bile acid metabolic process • female pregnancy • negative regulation of apoptotic process • cholesterol metabolic process • positive regulation of follicle-stimulating hormone secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of appetite • regulation of protein localization to nucleus • regulation of blood pressure • negative regulation of glucose import • leukocyte tethering or rolling • negative regulation of lipid storage • adipose tissue development • GO:1903106 positive regulation of insulin receptor signaling pathway • bone growth • positive regulation of receptor signaling pathway via JAK-STAT • glycerol biosynthetic process • positive regulation of luteinizing hormone secretion • fatty acid catabolic process • regulation of gluconeogenesis • response to estradiol • GO:0007243 intracellular signal transduction • adult feeding behavior • răspuns la hipoxie • regulation of natural killer cell proliferation • eating behavior • GO:0032737 positive regulation of cytokine production • regulation of cytokine production involved in inflammatory response • regulation of nitric-oxide synthase activity • response to activity • cellular response to leptin stimulus • regulation of cell cycle • regulation of natural killer cell mediated cytotoxicity • positive regulation of fat cell apoptotic process • positive regulation of cell population proliferation • regulation of lipoprotein lipid oxidation • positive regulation of phosphatidylinositol 3-kinase signaling • GO:0072468 signal transduction • regulation of bone remodeling • lipid metabolism • negative regulation of appetite by leptin-mediated signaling pathway • interleukin-12 production • positive regulation of tumor necrosis factor production • interleukin-6 production • response to insulin • tyrosine phosphorylation of STAT protein • Fagocitoză • energy reserve metabolic process • positive regulation of tyrosine phosphorylation of STAT protein • regulare a activității receptorilor • determination of adult lifespan • regulation of lipid biosynthetic process • positive regulation of cold-induced thermogenesis • aorta development • GO:0048552 regulation of catalytic activity • elastin metabolic process Surse: Amigo / QuickGO
Ortologi
Specie	Om	Șoarece
Entrez	3952	16846
Ensembl	ENSG00000174697	ENSMUSG00000059201
UniProt	P41159	P41160
RefSeq (mRNA)	NM_000230	NM_008493
RefSeq (proteine)	NP_000221	NP_032519
Localizare (UCSC)	Chr 7: 128.24 – 128.26 Mb	n/a
Căutare PubMed	[2]	[3]
Wikidata
Vedeți/Editați Om Vedeți/Editați Șoarece

Leptina (din limba greacă λεπτός (leptos) - subțire) este un hormon peptidic, cu o greutate de 16 kDa, care joacă un rol important în reglarea aportulului și cheltuielilor energetice, inclusiv apetitul și metabolismul. Leptina reglează rezervele de țesut adipos din organism. Leptina este sintetizată în principal de către adipocite. Gena leptinei se află pe cromozomul 7 la om.

Leptina acționează asupra receptorilor specifici din hipotalamus, inhibând apetitul prin:

• contracararea efectelor neuropeptidului Y (un stimulent puternic al ingestiei de alimente),
• contracararea efectelor anandamidelor (un alt stimulent puternic al apetitului, care se leagă de receptorii pentru THC),
• stimularea sintezei de α-MSH, care inhibă apetitul.

Inhibarea poftei de mâncare produsă de leptină este pe termen lung, comparativ cu inhibarea rapidă a apetitului de colecistokinină (CCK) și suprimarea lentă a foamei dintre mese mediată de PYY3-36. Absența leptinei (sau a receptorului specific), duce la ingestie necontrolată de alimente și, în final, la obezitate.

Note

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