SB-366791
Chemical compound
Identifiers | |
---|---|
| |
CAS Number |
|
PubChem CID |
|
ChemSpider |
|
UNII |
|
ChEBI |
|
ChEMBL |
|
Chemical and physical data | |
Formula | C16H14ClNO2 |
Molar mass | 287.74 g·mol−1 |
3D model (JSmol) |
|
| |
InChI
|
SB-366791 is a drug which acts as a potent and selective blocker of the TRPV1 ion channel. It has analgesic effects in animal studies, and is used in research into pain and inflammation.[1][2][3]
See also
- AMG-517
- AMG-9810
- Discovery and development of TRPV1 antagonists
References
- ^ Dell H (December 2003). "New compound fires up pain research". Drug Discovery Today. 8 (23): 1053. doi:10.1016/s1359-6446(03)02928-3. PMID 14693457.
- ^ Ma SX, Kim HC, Lee SY, Jang CG (December 2018). "TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens". Neurochemistry International. 121: 1–7. doi:10.1016/j.neuint.2018.10.009. PMID 30292787. S2CID 52929149.
- ^ Uchytilova E, Spicarova D, Palecek J (April 2021). "Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist". International Journal of Molecular Sciences. 22 (7): 3712. doi:10.3390/ijms22073712. PMC 8038144. PMID 33918267.
- v
- t
- e
TRP channel modulators
Activators | |
---|---|
Blockers |
|
Activators |
|
---|---|
Blockers |
|
Activators | |
---|---|
Blockers |
|
Activators | |
---|---|
Blockers |
See also: Receptor/signaling modulators • Ion channel modulators
This analgesic-related article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e