RAB17

Protein-coding gene in the species Homo sapiens
RAB17
Identifiers
AliasesRAB17, member RAS oncogene family
External IDsOMIM: 602206; MGI: 104640; HomoloGene: 7502; GeneCards: RAB17; OMA:RAB17 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for RAB17
Genomic location for RAB17
Band2q37.3Start237,574,322 bp[1]
End237,601,614 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for RAB17
Genomic location for RAB17
Band1 D|1 45.84 cMStart90,885,855 bp[2]
End90,897,383 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • renal medulla

  • body of pancreas

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • human kidney

  • mucosa of transverse colon

  • right uterine tube

  • mucosa of ileum

  • jejunal mucosa
Top expressed in
  • submandibular gland

  • Paneth cell

  • jejunum

  • medullary collecting duct

  • ileum

  • vestibular membrane of cochlear duct

  • duodenum

  • proximal tubule

  • parotid gland

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GDP binding
  • GTP binding
  • protein binding
  • GTPase activity
Cellular component
  • recycling endosome
  • endosome
  • cell projection
  • membrane
  • melanosome
  • plasma membrane
  • endocytic vesicle
  • intracellular anatomical structure
  • neuronal cell body
  • recycling endosome membrane
  • dendrite
  • basolateral plasma membrane
  • early endosome
  • apical plasma membrane
  • extracellular exosome
Biological process
  • regulation of endocytosis
  • regulation of filopodium assembly
  • regulation of synapse assembly
  • filopodium assembly
  • regulation of dendrite development
  • transcytosis
  • establishment of melanosome localization
  • melanosome transport
  • endocytic recycling
  • protein transport
  • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
  • cilium assembly
  • transport
  • intracellular protein transport
  • Rab protein signal transduction
  • small GTPase mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64284

19329

Ensembl

ENSG00000124839

ENSMUSG00000026304

UniProt

Q9H0T7

P35292

RefSeq (mRNA)

NM_022449

NM_001159725
NM_008998

RefSeq (protein)

NP_071894
NP_071894.1

NP_001153197
NP_033024

Location (UCSC)Chr 2: 237.57 – 237.6 MbChr 1: 90.89 – 90.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-17 is a protein that in humans is encoded by the RAB17 gene.[5][6]

In melanocytic cells RAB17 gene expression may be regulated by MITF.[7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124839 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026304 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem. 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.
  6. ^ "Entrez Gene: RAB17 RAB17, member RAS oncogene family".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization". J. Cell Biol. 121 (3): 553–64. doi:10.1083/jcb.121.3.553. PMC 2119572. PMID 8486736.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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