Poly ICLC

  (verify)

Poly ICLC is an immunostimulant. It is polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers carboxymethylcellulose and polylysine.[1] It is under trial for use in cancer.[2]

Poly I:C is a ligand for toll like receptor-3, which usually triggers on the structurally similar double-stranded RNA present in some viruses.[1]

References

  1. ^ a b Zhu X, Nishimura F, Sasaki K, et al. (2007). "Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models". Journal of Translational Medicine. 5: 10. doi:10.1186/1479-5876-5-10. PMC 1802742. PMID 17295916.
  2. ^ "Intervention Dynamic Trial Listing Page". National Cancer Institute. 13 June 2017.

External links

  • National Cancer Institute: poly ICLC
  • v
  • t
  • e
Immunostimulants (L03)
Endogenous
Cytokines
Colony-stimulating factors
  • G-CSF
    • Efbemalenograstim alfa
    • Eflapegrastim
    • Filgrastim / Lipegfilgrastim / Pegfilgrastim
    • Lenograstim
  • GM-CSF
    • Molgramostim
    • Sargramostim
  • SCF
Interferons
Interleukins
Other protein / peptide
Other
Exogenous


Stub icon

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e