POLE3

Protein-coding gene in the species Homo sapiens
POLE3
Identifiers
AliasesPOLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDsOMIM: 607267 MGI: 1933378 HomoloGene: 9694 GeneCards: POLE3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for POLE3
Genomic location for POLE3
Band9q32Start113,407,235 bp[1]
End113,410,675 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for POLE3
Genomic location for POLE3
Band4|4 B3Start62,440,886 bp[2]
End62,443,305 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • monocyte

  • human penis

  • ganglionic eminence

  • rectum

  • bone marrow

  • cerebellar hemisphere

  • right adrenal gland

  • skin of abdomen

  • left adrenal gland
Top expressed in
  • spermatocyte

  • yolk sac

  • secondary oocyte

  • seminiferous tubule

  • morula

  • molar

  • maxillary prominence

  • ganglionic eminence

  • medial ganglionic eminence

  • neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • protein binding
  • protein heterodimerization activity
  • histone acetyltransferase activity
Cellular component
  • epsilon DNA polymerase complex
  • nucleus
  • nucleoplasm
Biological process
  • DNA replication
  • histone H3 acetylation
  • DNA biosynthetic process
  • G1/S transition of mitotic cell cycle
  • cellular response to DNA damage stimulus
  • CENP-A containing chromatin assembly
  • cellular response to gamma radiation
  • DNA replication initiation
  • telomere maintenance via semi-conservative replication
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54107

59001

Ensembl

ENSG00000148229

ENSMUSG00000028394

UniProt

Q9NRF9

Q9JKP7

RefSeq (mRNA)

NM_001278255
NM_017443

NM_021498

RefSeq (protein)

NP_001265184
NP_059139

NP_067473

Location (UCSC)Chr 9: 113.41 – 113.41 MbChr 4: 62.44 – 62.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[5][6][7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][7]

Interactions

POLE3 has been shown to interact with SMARCA5.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
  6. ^ a b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
  7. ^ a b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Bolognese F, Imbriano C, Caretti G, Mantovani R (2000). "Cloning and characterization of the histone-fold proteins YBL1 and YCL1". Nucleic Acids Res. 28 (19): 3830–8. doi:10.1093/nar/28.19.3830. PMC 110757. PMID 11000277.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


  • v
  • t
  • e