PIGV

Protein-coding gene in the species Homo sapiens
PIGV
Identifiers
AliasesPIGV, GPI-MT-II, HPMRS1, PIG-V, phosphatidylinositol glycan anchor biosynthesis class V
External IDsOMIM: 610274; MGI: 2442480; HomoloGene: 5354; GeneCards: PIGV; OMA:PIGV - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PIGV
Genomic location for PIGV
Band1p36.11Start26,787,472 bp[1]
End26,798,398 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PIGV
Genomic location for PIGV
Band4|4 D2.3Start133,387,698 bp[2]
End133,399,958 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • oocyte

  • right testis

  • left testis

  • germinal epithelium

  • bronchial epithelial cell

  • secondary oocyte

  • gonad

  • parotid gland

  • kidney tubule
Top expressed in
  • otic vesicle

  • granulocyte

  • interventricular septum

  • ascending aorta

  • aortic valve

  • spermatocyte

  • yolk sac

  • right kidney

  • muscle of thigh

  • hand
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • mannosyltransferase activity
  • glycosyltransferase activity
  • transferase activity
  • glycolipid mannosyltransferase activity
Cellular component
  • membrane
  • mannosyltransferase complex
  • endoplasmic reticulum
  • integral component of membrane
  • endoplasmic reticulum membrane
Biological process
  • GPI anchor biosynthetic process
  • preassembly of GPI anchor in ER membrane
  • mannosylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55650

230801

Ensembl

ENSG00000060642

ENSMUSG00000043257

UniProt

Q9NUD9

Q7TPN3

RefSeq (mRNA)

NM_017837
NM_001202554

NM_001145955
NM_001145956
NM_178698
NM_001356466

RefSeq (protein)
NP_001189483
NP_060307
NP_001361407
NP_001361409
NP_001361410

NP_001361411
NP_001361412
NP_001361413
NP_001361414
NP_001361415

NP_001139427
NP_001139428
NP_848813
NP_001343395

Location (UCSC)Chr 1: 26.79 – 26.8 MbChr 4: 133.39 – 133.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000060642 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043257 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T (Mar 2005). "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol". J Biol Chem. 280 (10): 9489–97. doi:10.1074/jbc.M413867200. PMID 15623507.
  6. ^ "Entrez Gene: PIGV phosphatidylinositol glycan anchor biosynthesis, class V".

Further reading

  • Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Fabre AL, Orlean P, Taron CH (2005). "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly". FEBS J. 272 (5): 1160–8. doi:10.1111/j.1742-4658.2005.04551.x. PMID 15720390. S2CID 25106178.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • v
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Synthesis
Malonyl-CoA synthesis
Fatty acid synthesis/
Fatty acid synthase
Fatty acid desaturases
Triacyl glycerol
Degradation
Acyl transport
Beta oxidation
General
Unsaturated
Odd chain
Other
To acetyl-CoA
Aldehydes


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