PGPEP1

Protein-coding gene in the species Homo sapiens
PGPEP1
Identifiers
AliasesPGPEP1, PAP-I, PGP, PGP-I, PGPI, Pcp, pyroglutamyl-peptidase I, PGI
External IDsOMIM: 610694; MGI: 1913772; HomoloGene: 9793; GeneCards: PGPEP1; OMA:PGPEP1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PGPEP1
Genomic location for PGPEP1
Band19p13.11Start18,340,598 bp[1]
End18,369,950 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for PGPEP1
Genomic location for PGPEP1
Band8|8 B3.3Start70,646,435 bp[2]
End70,660,388 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardia

  • renal medulla

  • tendon of biceps brachii

  • pylorus

  • inferior ganglion of vagus nerve

  • internal globus pallidus

  • external globus pallidus

  • vena cava

  • ventral tegmental area

  • subthalamic nucleus
Top expressed in
  • right kidney

  • proximal tubule

  • ventricular zone

  • human kidney

  • epithelium of small intestine

  • neural tube

  • adrenal gland

  • yolk sac

  • jejunum

  • ileum
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • peptidase activity
  • cysteine-type peptidase activity
  • hydrolase activity
  • pyroglutamyl-peptidase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54858

66522

Ensembl

ENSG00000130517

ENSMUSG00000056204

UniProt

Q9NXJ5

Q9ESW8

RefSeq (mRNA)
NM_001300927
NM_001308366
NM_017712
NM_001329471
NM_001329476

NM_001329477
NM_001329478

NM_023217

RefSeq (protein)
NP_001287856
NP_001295295
NP_001316400
NP_001316405
NP_001316406

NP_001316407
NP_060182

NP_075706

Location (UCSC)Chr 19: 18.34 – 18.37 MbChr 8: 70.65 – 70.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The PGPEP1 gene in humans encodes the enzyme Pyroglutamyl-peptidase I.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130517 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056204 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PGPEP1 pyroglutamyl-peptidase I".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Valdivia A, Irazusta J, Fernández D, et al. (2005). "Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia". Regul. Pept. 122 (2): 79–84. doi:10.1016/j.regpep.2004.05.005. PMID 15380924. S2CID 24844740.
  • Minderman H, O'Loughlin KL, Pendyala L, Baer MR (2004). "VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein". Clin. Cancer Res. 10 (5): 1826–34. doi:10.1158/1078-0432.CCR-0914-3. PMID 15014037.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Dando PM, Fortunato M, Strand GB, et al. (2003). "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme". Protein Expr. Purif. 28 (1): 111–9. doi:10.1016/S1046-5928(02)00632-0. PMID 12651114.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gil J, Larrinaga G, Meana JJ, et al. (2002). "Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study". Neuropeptides. 35 (5–6): 276–84. doi:10.1054/npep.2001.0870. PMID 12030812. S2CID 39976173.
  • Charli JL, Mendez M, Vargas MA, et al. (1990). "Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices". Neuropeptides. 14 (3): 191–6. doi:10.1016/0143-4179(89)90044-9. PMID 2575716. S2CID 13735633.


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