Protein-coding gene in the species Homo sapiens
| MAPK8IP3 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | MAPK8IP3, JIP3, JSAP1, SYD2, syd, JIP-3, mitogen-activated protein kinase 8 interacting protein 3 |
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| External IDs | OMIM: 605431; MGI: 1353598; HomoloGene: 22790; GeneCards: MAPK8IP3; OMA:MAPK8IP3 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 16 (human)[1] |
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| | Band | 16p13.3 | Start | 1,706,183 bp[1] |
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| End | 1,770,317 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 17 (mouse)[2] |
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| | Band | 17 A3.3|17 12.53 cM | Start | 25,111,127 bp[2] |
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| End | 25,155,951 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right hemisphere of cerebellum
- right frontal lobe
- anterior pituitary
- prefrontal cortex
- granulocyte
- sural nerve
- cingulate gyrus
- left ovary
- anterior cingulate cortex
- right ovary
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| | Top expressed in | - dentate gyrus of hippocampal formation granule cell
- superior frontal gyrus
- neural layer of retina
- primary visual cortex
- perirhinal cortex
- entorhinal cortex
- central gray substance of midbrain
- cerebellar cortex
- superior colliculus
- CA3 field
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - signaling receptor complex adaptor activity
- protein binding
- MAP-kinase scaffold activity
- JUN kinase binding
- kinesin binding
| | Cellular component | - cytoplasm
- Golgi membrane
- axon
- dendrite
- cell body
- perinuclear region of cytoplasm
- axon cytoplasm
- Golgi apparatus
- growth cone
- cytoplasmic vesicle
- cell projection
| | Biological process | - vesicle-mediated transport
- regulation of JNK cascade
- axon regeneration
- axon development
- anterograde axonal protein transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001040439
NM_015133
NM_001318852 |
| NM_001163447
NM_001163448
NM_001163449
NM_001163450
NM_001163451
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NM_001163453
NM_013931 |
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| RefSeq (protein) | |
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NP_001035529
NP_001305781
NP_055948 |
| NP_001156919
NP_001156920
NP_001156921
NP_001156922
NP_001156923
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NP_001156925
NP_038959 |
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| Location (UCSC) | Chr 16: 1.71 – 1.77 Mb | Chr 17: 25.11 – 25.16 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.[5][6][7]
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]
Interactions
MAPK8IP3 has been shown to interact with ASK1,[8] C-Raf,[5][9] PTK2,[10] MAPK10,[5][6][8] Mitogen-activated protein kinase 9,[5][6] MAPK8,[5][6] MAP2K1,[5][9] KLC2,[11] MAP2K7,[6][8] KLC1,[11] MAPK8IP2[6] and MAP2K4.[5][8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138834 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024163 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e f g Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
- ^ a b c d e f Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
- ^ a b "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3".
- ^ a b c d Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43). United States: 40703–9. doi:10.1074/jbc.M202004200. hdl:2297/2692. ISSN 0021-9258. PMID 12189133.
- ^ a b Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. 275 (51). UNITED STATES: 39815–8. doi:10.1074/jbc.C000403200. ISSN 0021-9258. PMID 11044439.
- ^ Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene. 21 (42). England: 6488–97. doi:10.1038/sj.onc.1205840. ISSN 0950-9232. PMID 12226752.
- ^ a b Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4). UNITED STATES: 583–94. doi:10.1016/S0092-8674(00)00162-8. ISSN 0092-8674. PMID 11106729. S2CID 247102.
Further reading
- Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Kuboki Y, Ito M, Takamatsu N, et al. (2001). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. 275 (51): 39815–8. doi:10.1074/jbc.C000403200. PMID 11044439.
- Bowman AB, Kamal A, Ritchings BW, et al. (2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.
- Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
- Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
- Akechi M, Ito M, Uemura K, et al. (2001). "Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system". Neurosci. Res. 39 (4): 391–400. doi:10.1016/S0168-0102(01)00194-8. PMID 11274738. S2CID 37577286.
- Byrd DT, Kawasaki M, Walcoff M, et al. (2002). "UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans". Neuron. 32 (5): 787–800. doi:10.1016/S0896-6273(01)00532-3. PMID 11738026. S2CID 16942260.
- Matsuura H, Nishitoh H, Takeda K, et al. (2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. hdl:2297/2692. PMID 12189133.
- Takino T, Yoshioka K, Miyamori H, et al. (2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene. 21 (42): 6488–97. doi:10.1038/sj.onc.1205840. PMID 12226752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Morita N, Iizuka K, Murakami T, Kawaguchi H (2005). "N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress". Mol. Cell. Biochem. 262 (1–2): 71–8. doi:10.1023/B:MCBI.0000038218.09259.1c. PMID 15532711. S2CID 23799480.
- Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
- Song JJ, Lee YJ (2005). "Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators". J. Biol. Chem. 280 (29): 26845–55. doi:10.1074/jbc.M502318200. PMID 15911620.
- Takino T, Nakada M, Miyamori H, et al. (2006). "JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration". J. Biol. Chem. 280 (45): 37772–81. doi:10.1074/jbc.M505241200. PMID 16141199.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
