IQGAP2

Protein-coding gene in the species Homo sapiens

IQGAP2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3IEZ, 4EZA

Identifiers

Aliases

IQGAP2, IQ motif containing GTPase activating protein 2

External IDs

OMIM: 605401; MGI: 2449975; HomoloGene: 101543; GeneCards: IQGAP2; OMA:IQGAP2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q13.3	Start	76,403,285 bp^[1]
Band	5q13.3	End	76,708,132 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 D1\|13 50.26 cM	Start	95,763,682 bp^[2]
Band	13 D1\|13 50.26 cM	End	96,028,991 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

ventricular zone

glomerulus

metanephric glomerulus

secondary oocyte

liver

right lobe of liver

duodenum

parotid gland

monocyte

Top expressed in

ciliary body

retinal pigment epithelium

parotid gland

iris

left lobe of liver

epithelium of stomach

submandibular gland

left colon

jejunum

lacrimal gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	Arp2/3 complex binding GTPase inhibitor activity actin filament binding actin binding phosphatidylinositol-3,4,5-trisphosphate binding calmodulin binding
Cellular component	cytoplasm filamentous actin cytosol filopodium microvillus cell surface actin cytoskeleton microtubule extracellular exosome lamellipodium plasma membrane secretory granule membrane
Biological process	thrombin-activated receptor signaling pathway regulation of GTPase activity Arp2/3 complex-mediated actin nucleation signal transduction negative regulation of GTPase activity neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10788


544963

Ensembl


ENSG00000145703


ENSMUSG00000021676

UniProt


Q13576


Q3UQ44

RefSeq (mRNA)


NM_001285460 NM_001285461 NM_001285462 NM_006633


NM_027711

RefSeq (protein)


NP_001272389 NP_001272390 NP_001272391 NP_006624


NP_081987

Location (UCSC)

Chr 5: 76.4 – 76.71 Mb

Chr 13: 95.76 – 96.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.^[5]^[6]

Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.^[6]

Interactions

IQGAP2 has been shown to interact with CDC42^[5] and RAC1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145703 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021676 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. doi:10.1128/mcb.16.9.4869. PMC 231489. PMID 8756646.
^ ^a ^b "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".

McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi:10.1074/jbc.271.36.21732. PMID 8702968.
Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine. 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (2002). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood. 101 (8): 3021–8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
Wang H, Huo R, Xu M, Lu L, Xu Z, Li J, Zhou Z, Sha J (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. doi:10.1080/10425170400009012. PMID 15621655. S2CID 22014226.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.