IGF2BP2

Protein-coding gene in the species Homo sapiens

IGF2BP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CQH

Identifiers
AliasesIGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDsOMIM: 608289; MGI: 1890358; HomoloGene: 4774; GeneCards: IGF2BP2; OMA:IGF2BP2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IGF2BP2
Genomic location for IGF2BP2
Band3q27.2Start185,643,130 bp[1]
End185,825,042 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for IGF2BP2
Genomic location for IGF2BP2
Band16|16 B1Start21,877,759 bp[2]
End21,982,049 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • ventricular zone

  • sural nerve

  • stromal cell of endometrium

  • embryo

  • ganglionic eminence

  • amniotic fluid

  • bronchial epithelial cell

  • mucosa of paranasal sinus

  • cartilage tissue
Top expressed in
  • primitive streak

  • medullary collecting duct

  • primary oocyte

  • Paneth cell

  • fossa

  • renal corpuscle

  • condyle

  • tail of embryo

  • genital tubercle

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • mRNA 5'-UTR binding
  • protein binding
  • mRNA binding
  • translation regulator activity
  • mRNA 3'-UTR binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • cytoplasm
  • cytoskeleton
  • nucleus
  • cytosol
Biological process
  • anatomical structure morphogenesis
  • negative regulation of translation
  • mRNA transport
  • regulation of translation
  • regulation of mRNA stability
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10644

319765

Ensembl

ENSG00000073792

ENSMUSG00000033581

UniProt

Q9Y6M1

Q5SF07

RefSeq (mRNA)
NM_001007225
NM_001291869
NM_001291872
NM_001291873
NM_001291874

NM_001291875
NM_006548

NM_183029

RefSeq (protein)
NP_001007226
NP_001278798
NP_001278801
NP_001278802
NP_001278803

NP_001278804
NP_006539

NP_898850

Location (UCSC)Chr 3: 185.64 – 185.83 MbChr 16: 21.88 – 21.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.[5][6][7]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073792 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033581 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC 2193003. PMID 10190901.
  6. ^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
  7. ^ a b "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

Further reading

  • Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260. S2CID 8767105.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497. S2CID 30993043.
  • Brants JR, Ayoubi TA, Chada K, et al. (2004). "Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2". FEBS Lett. 569 (1–3): 277–83. doi:10.1016/j.febslet.2004.05.075. PMID 15225648. S2CID 31167314.
  • Ping S, Wang S, Zhang J, Peng X (2005). "Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells". Int. J. Biochem. Cell Biol. 37 (3): 616–27. doi:10.1016/j.biocel.2004.08.007. PMID 15618018.
  • Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203–12. doi:10.1530/rep.1.00664. PMID 16049158.
  • Natkunam Y, Vainer G, Chen J, et al. (2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176–83. doi:10.3324/haematol.10724. PMID 17296566.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Cleynen I, Brants JR, Peeters K, et al. (2007). "HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB". Mol. Cancer Res. 5 (4): 363–72. doi:10.1158/1541-7786.MCR-06-0331. PMID 17426251. S2CID 21026667.
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  • 2cqh: Solution structure of the RNA binding domain of IGF-II mRNA-binding protein 2
    2cqh: Solution structure of the RNA binding domain of IGF-II mRNA-binding protein 2


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