FLRT3

FLRT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CMN, 5CMP
Identifiers
Aliases	FLRT3, HH21, fibronectin leucine rich transmembrane protein 3
External IDs	OMIM: 604808; MGI: 1918686; HomoloGene: 8322; GeneCards: FLRT3; OMA:FLRT3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.1 Start 14,322,985 bp[1] End 14,337,614 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F3 Start 140,492,834 bp[2] End 140,513,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell lower lobe of lung pericardium Brodmann area 23 middle temporal gyrus renal medulla visceral pleura germinal epithelium jejunal mucosa hair follicle Top expressed in hand abdominal wall hair follicle otolith organ ganglionic eminence maxillary prominence olfactory tubercle utricle skin of abdomen medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein homodimerization activity fibroblast growth factor receptor binding protein kinase inhibitor activity protein binding chemorepellent activity Cellular component cytoplasm axon terminus integral component of membrane synaptic membrane cell projection endoplasmic reticulum membrane membrane cell-cell junction focal adhesion axonal growth cone integral component of plasma membrane extracellular region axon endoplasmic reticulum extracellular space cytosol plasma membrane cell junction extracellular matrix glutamatergic synapse integral component of postsynaptic membrane Biological process negative chemotaxis negative regulation of protein kinase activity cytokine-mediated signaling pathway head development neuron projection extension axon guidance multicellular organism development heart development cell adhesion response to axon injury embryonic morphogenesis proepicardium cell migration involved in pericardium morphogenesis synapse assembly neuron projection development negative regulation of receptor signaling pathway via JAK-STAT positive regulation of synapse assembly fibroblast growth factor receptor signaling pathway cell-cell adhesion via plasma-membrane adhesion molecules synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23767 71436 Ensembl ENSG00000125848 ENSMUSG00000051379 UniProt Q9NZU0 Q8BGT1 RefSeq (mRNA) NM_013281 NM_198391 NM_001172160 NM_178382 RefSeq (protein) NP_037413 NP_938205 NP_001165631 NP_848469 Location (UCSC) Chr 20: 14.32 – 14.34 Mb Chr 2: 140.49 – 140.51 Mb PubMed search [3] [4]
Wikidata
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Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.^[5][6]

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]

References

Further reading