DNAJC13

Protein-coding gene in the species Homo sapiens
DNAJC13
Identifiers
AliasesDNAJC13, RME8, PARK21, DnaJ heat shock protein family (Hsp40) member C13
External IDsOMIM: 614334; MGI: 2676368; HomoloGene: 13574; GeneCards: DNAJC13; OMA:DNAJC13 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for DNAJC13
Genomic location for DNAJC13
Band3q22.1Start132,417,502 bp[1]
End132,539,032 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DNAJC13
Genomic location for DNAJC13
Band9|9 F1Start104,028,481 bp[2]
End104,140,129 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • saphenous vein

  • trabecular bone

  • superficial temporal artery

  • parietal pleura

  • trigeminal ganglion

  • tibia

  • visceral pleura

  • stromal cell of endometrium

  • germinal epithelium
Top expressed in
  • secondary oocyte

  • cumulus cell

  • saccule

  • otic placode

  • kidney

  • ileum

  • ciliary body

  • morula

  • cochlea

  • placenta
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • lysosomal membrane
  • endosome
  • WASH complex
  • early endosome membrane
  • endosome membrane
  • extracellular exosome
  • early endosome
  • membrane
  • intracellular membrane-bounded organelle
  • cytosol
  • plasma membrane
  • secretory granule membrane
  • azurophil granule membrane
Biological process
  • protein transport
  • regulation of early endosome to late endosome transport
  • regulation of early endosome to recycling endosome transport
  • osteoblast differentiation
  • endosome organization
  • neutrophil degranulation
  • receptor-mediated endocytosis
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23317

235567

Ensembl

ENSG00000138246

ENSMUSG00000032560

UniProt

O75165

n/a

RefSeq (mRNA)

NM_015268
NM_001329126
NM_173823

NM_001163026
NM_001359740

RefSeq (protein)

NP_001316055
NP_056083

n/a

Location (UCSC)Chr 3: 132.42 – 132.54 MbChr 9: 104.03 – 104.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138246 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032560 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13".

Further reading

  • Girard M, Poupon V, Blondeau F, McPherson PS (2006). "The DnaJ-domain protein RME-8 functions in endosomal trafficking". J. Biol. Chem. 280 (48): 40135–43. doi:10.1074/jbc.M505036200. PMID 16179350.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Chang HC, Hull M, Mellman I (2004). "The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila". J. Cell Biol. 164 (7): 1055–64. doi:10.1083/jcb.200311084. PMC 2172058. PMID 15051737.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Volz A, Melkaoui R, Hildebrandt F, Omran H (2003). "Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-Løken syndrome type 3". Cytogenet. Genome Res. 97 (3–4): 163–6. doi:10.1159/000066617. PMID 12438707. S2CID 438753.
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • v
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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