CDH10

Protein-coding gene in the species Homo sapiens
CDH10
Identifiers
AliasesCDH10, cadherin 10
External IDsOMIM: 604555 MGI: 107436 HomoloGene: 68530 GeneCards: CDH10
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDH10
Genomic location for CDH10
Band5p14.2-p14.1Start24,487,100 bp[1]
End24,644,978 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CDH10
Genomic location for CDH10
Band15 A2|15 8.2 cMStart18,819,033 bp[2]
End19,014,322 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • middle temporal gyrus

  • Brodmann area 46

  • orbitofrontal cortex

  • superior frontal gyrus

  • cerebellar hemisphere

  • entorhinal cortex

  • prefrontal cortex

  • dorsolateral prefrontal cortex

  • Brodmann area 9
Top expressed in
  • barrel cortex

  • prefrontal cortex

  • Region I of hippocampus proper

  • facial motor nucleus

  • ventral tegmental area

  • anterior horn of spinal cord

  • primary motor cortex

  • dorsal tegmental nucleus

  • olfactory bulb

  • habenula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • metal ion binding
  • cytoskeletal protein binding
  • protein homodimerization activity
  • cadherin binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • glutamatergic synapse
  • GABA-ergic synapse
  • integral component of presynaptic active zone membrane
  • integral component of postsynaptic specialization membrane
  • cell surface
  • catenin complex
Biological process
  • cell adhesion
  • adherens junction organization
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • cell-cell adhesion
  • cell-cell junction assembly
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
  • cell-cell adhesion mediated by cadherin
  • cell morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1008

320873

Ensembl

ENSG00000040731

ENSMUSG00000022321

UniProt

Q9Y6N8

P70408

RefSeq (mRNA)

NM_001190450
NM_006727
NM_001317222
NM_001317224
NM_001362460

NM_009865
NM_001316758

RefSeq (protein)

NP_001304151
NP_001304153
NP_006718
NP_001349389
NP_001304153.1

NP_001303687
NP_033995

Location (UCSC)Chr 5: 24.49 – 24.64 MbChr 15: 18.82 – 19.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.[5][6]

Clinical significance

An association with autism has been suggested.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000040731 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022321 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: cadherin 10".
  6. ^ Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
  7. ^ Wang K, Zhang H, Ma D, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

External links

Further reading

  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
  • Wang K, Zhang H, Ma D, et al. (2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.
  • Potkin SG, Guffanti G, Lakatos A, et al. (2009). "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease". PLOS ONE. 4 (8): e6501. Bibcode:2009PLoSO...4.6501P. doi:10.1371/journal.pone.0006501. PMC 2719581. PMID 19668339.
  • Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex". J. Comp. Neurol. 453 (4): 372–88. doi:10.1002/cne.10424. PMID 12389209. S2CID 25610258.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999). "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14". FEBS Lett. 452 (3): 328–34. doi:10.1016/S0014-5793(99)00672-9. PMID 10386616. S2CID 44714251.
  • Hillier LD, Lennon G, Becker M, et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219. S2CID 21501093.
  • Ma D, Salyakina D, Jaworski JM, et al. (2009). "A genome-wide association study of autism reveals a common novel risk locus at 5p14.1". Ann. Hum. Genet. 73 (Pt 3): 263–73. doi:10.1111/j.1469-1809.2009.00523.x. PMC 2918410. PMID 19456320.
  • Hülsken J, Birchmeier W, Behrens J (1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". J. Cell Biol. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.


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