BDP1

Protein-coding gene in the species Homo sapiens
BDP1
Identifiers
AliasesBDP1, HSA238520, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112, TFIIIB''
External IDsOMIM: 607012; MGI: 1347077; HomoloGene: 34582; GeneCards: BDP1; OMA:BDP1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for BDP1
Genomic location for BDP1
Band5q13.2Start71,455,651 bp[1]
End71,567,820 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for BDP1
Genomic location for BDP1
Band13 D1|13 52.92 cMStart100,017,994 bp[2]
End100,104,070 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Achilles tendon

  • epithelium of colon

  • corpus callosum

  • right uterine tube

  • testicle

  • tonsil

  • bone marrow cells

  • ventricular zone

  • endometrium
Top expressed in
  • superior cervical ganglion

  • hand

  • otolith organ

  • utricle

  • cumulus cell

  • tail of embryo

  • primitive streak

  • medullary collecting duct

  • condyle

  • fossa
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • TFIIIC-class transcription factor complex binding
  • RNA polymerase III general transcription initiation factor activity
Cellular component
  • nucleus
  • transcription factor TFIIIB complex
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase III
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • RNA polymerase III preinitiation complex assembly
  • transcription by RNA polymerase III
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55814

544971

Ensembl

ENSG00000274803
ENSG00000273873
ENSG00000145734

ENSMUSG00000049658

UniProt

A6H8Y1
H7C5U4

Q571C7

RefSeq (mRNA)

NM_018429

NM_001081061

RefSeq (protein)

NP_060899

NP_001074530

Location (UCSC)Chr 5: 71.46 – 71.57 MbChr 13: 100.02 – 100.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[5][6][7]

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[7]

References

  1. ^ a b c ENSG00000273873, ENSG00000145734 GRCh38: Ensembl release 89: ENSG00000274803, ENSG00000273873, ENSG00000145734 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049658 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  6. ^ Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. doi:10.1101/gad.836400. PMC 316990. PMID 11040218.
  7. ^ a b "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB".

Further reading

  • Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. doi:10.1074/jbc.272.23.14755. PMID 9169441.
  • Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Kelter AR, Herchenbach J, Wirth B (2001). "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1". Genomics. 70 (3): 315–26. doi:10.1006/geno.2000.6396. PMID 11161782.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hu P, Wu S, Hernandez N (2003). "A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2". Mol. Cell. 12 (3): 699–709. doi:10.1016/j.molcel.2003.08.011. PMID 14527415.
  • Fairley JA, Scott PH, White RJ (2003). "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo". EMBO J. 22 (21): 5841–50. doi:10.1093/emboj/cdg544. PMC 275401. PMID 14592981.
  • Weser S, Gruber C, Hafner HM, et al. (2004). "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity". J. Biol. Chem. 279 (26): 27022–9. doi:10.1074/jbc.M312790200. PMID 15096501.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Hu P, Samudre K, Wu S, et al. (2004). "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression". Mol. Cell. 16 (1): 81–92. doi:10.1016/j.molcel.2004.09.008. PMID 15469824.
  • Schoenen F, Wirth B (2006). "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB". Biol. Chem. 387 (3): 277–84. doi:10.1515/BC.2006.037. PMID 16542149. S2CID 28560128.
  • Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.

External links


  • v
  • t
  • e