BAG5

Protein-coding gene in the species Homo sapiens
BAG5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D9D, 3A8Y

Identifiers
AliasesBAG5, BAG-5, BCL2 associated athanogene 5, BAG cochaperone 5, CMD2F
External IDsOMIM: 603885; MGI: 1917619; HomoloGene: 3584; GeneCards: BAG5; OMA:BAG5 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for BAG5
Genomic location for BAG5
Band14q32.33Start103,556,545 bp[1]
End103,562,657 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for BAG5
Genomic location for BAG5
Band12|12 F1Start111,675,922 bp[2]
End111,679,691 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • skin of thigh

  • skin of hip

  • endothelial cell

  • caput epididymis

  • gums

  • corpus epididymis

  • gingival epithelium
Top expressed in
  • seminiferous tubule

  • spermatid

  • saccule

  • otic vesicle

  • spermatocyte

  • otic placode

  • supraoptic nucleus

  • dorsal striatum

  • interventricular septum

  • aortic valve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • chaperone binding
  • protein binding
  • protein kinase binding
  • ubiquitin protein ligase binding
  • adenyl-nucleotide exchange factor activity
Cellular component
  • cytosol
  • membrane
  • mitochondrion
  • inclusion body
  • perinuclear region of cytoplasm
  • nucleus
Biological process
  • neuron death
  • negative regulation of neuron projection development
  • Golgi organization
  • regulation of inclusion body assembly
  • negative regulation of protein ubiquitination
  • protein folding
  • negative regulation of ubiquitin-protein transferase activity
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process
  • regulation of cellular response to heat
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • negative regulation of protein refolding
  • regulation of ubiquitin-protein transferase activity
  • protein stabilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9529

70369

Ensembl

ENSG00000166170

ENSMUSG00000049792

UniProt

Q9UL15

Q8CI32

RefSeq (mRNA)

NM_004873
NM_001015048
NM_001015049

NM_027404
NM_001324480
NM_001324481
NM_001324482

RefSeq (protein)

NP_001015048
NP_001015049
NP_004864

NP_001311409
NP_001311410
NP_001311411
NP_081680

Location (UCSC)Chr 14: 103.56 – 103.56 MbChr 12: 111.68 – 111.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.[5][6][7]

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166170 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049792 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
  6. ^ Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron. 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
  7. ^ a b "Entrez Gene: BAG5 BCL2-associated athanogene 5".

External links

Further reading

  • Takayama S, Sato T, Krajewski S, et al. (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell. 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Höhfeld J, Jentsch S (1997). "GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1". EMBO J. 16 (20): 6209–16. doi:10.1093/emboj/16.20.6209. PMC 1326305. PMID 9321400.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
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  • 1ugo: Solution structure of the first Murine BAG domain of Bcl2-associated athanogene 5
    1ugo: Solution structure of the first Murine BAG domain of Bcl2-associated athanogene 5
  • 2d9d: Solution structure of the BAG domain (275-350) of BAG-family molecular chaperone regulator-5
    2d9d: Solution structure of the BAG domain (275-350) of BAG-family molecular chaperone regulator-5


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