ABTB1

Protein-coding gene in the species Homo sapiens
ABTB1
Identifiers
AliasesABTB1, BPOZ, BTB3, BTBD21, EF1ABP, PP2259, ankyrin repeat and BTB domain containing 1
External IDsOMIM: 608308; MGI: 1933148; HomoloGene: 32731; GeneCards: ABTB1; OMA:ABTB1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ABTB1
Genomic location for ABTB1
Band3q21.3Start127,672,935 bp[1]
End127,680,926 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for ABTB1
Genomic location for ABTB1
Band6|6 D1Start88,812,896 bp[2]
End88,818,966 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • granulocyte

  • blood

  • spleen

  • apex of heart

  • tibial nerve

  • right lung

  • gastric mucosa

  • canal of the cervix

  • monocyte
Top expressed in
  • granulocyte

  • Jacobson's organ

  • blood

  • muscle of thigh

  • neural layer of retina

  • right kidney

  • spermatocyte

  • superior frontal gyrus

  • lip

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • translation elongation factor activity
  • ubiquitin protein ligase binding
Cellular component
  • plasma membrane
  • nucleolus
  • SCF ubiquitin ligase complex
  • cytoplasm
  • cytosol
  • ubiquitin ligase complex
Biological process
  • translational elongation
  • protein biosynthesis
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • regulation of proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80325

80283

Ensembl

ENSG00000114626

ENSMUSG00000030083

UniProt

Q969K4

Q99LJ2

RefSeq (mRNA)

NM_032548
NM_172027
NM_172028

NM_030251
NM_001362152

RefSeq (protein)

NP_115937
NP_742024

NP_084527
NP_001349081

Location (UCSC)Chr 3: 127.67 – 127.68 MbChr 6: 88.81 – 88.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.[5][6][7]

Function

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114626 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030083 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun. 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360.
  6. ^ Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141.
  7. ^ a b "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1".

External links

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.



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